Currently, traditional cancer detection methods still have significant limitations:
· Tissue biopsy is invasive and sampling is difficult
· Imaging detection relies on tumors reaching a certain size
· Tumor marker testing suffers from insufficient sensitivity and specificity, leading to misdiagnosis
Circulating tumor cells (CTCs), as a cutting-edge technology for early cancer screening and precision monitoring, can easily detect tumor cells at an early stage, seizing the optimal opportunity for prevention and treatment.
Our company’s self-developed inertial microfluidic liquid biopsy platform has achieved disruptive innovation in the field of CTC capture, combining high throughput, gentle processing, low cost, high sensitivity, and high specificity — opening a new chapter in precision medicine and early cancer screening.
Using the Labyrinth Cell Sorter, sensitivity reaches 84.4%, specificity reaches 82.4%, while maintaining exceptionally high cell viability.
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While ensuring high accuracy for early cancer screening, our technology enables gentle and efficient capture of circulating tumor cells (CTCs), preserving cell integrity and viability to the greatest extent. The captured cells can be directly used for in vitro culture, drug susceptibility testing, and mouse xenograft models, providing a reliable cellular foundation for basic research, drug development, and personalized treatment — realizing a truly integrated liquid biopsy platform "from detection to functional studies."
2.Jin P,Li H,Xie M,Tang J,Zou S,Wang R,Yu B,Chen Tand ZhangJ(2024)Thecapture of circulating tumor cells byLabyrinth system as a tool for earlystage lung cancer detection.Front.Oncol.14:1474015.doi:10.3389/fonc.2024.1474015
Leveraging the fact that tumor cells are physically larger than other cells in the blood, we use hydrodynamic principles to cause CTCs to converge into a focused stream within the microfluidic system, with different cell types being separated and directed through different channels.
Enriched circulating tumor cells (CTCs) and CTC clusters
Additionally, we can customize the design of microfluidic chips according to specific application needs, suitable for various sample types including blood, urine, ascites, bile, etc., enabling efficient isolation of multiple cell types including tumor cells and stem cells, and meeting diverse usage scenarios.
The Labyrinth® Inertial Microfluidic Liquid Biopsy System is a device designed for rare cell enrichment. It can be applied to various body fluid samples (such as blood, ascites, pleural effusion, bile, etc.), enabling efficient isolation of multiple rare cell types, including circulating tumor cells (CTCs) and CTC clusters.
